Vitreous vascular endothelial growth factor level during gestation
Archives of Gynecology and Obstetrics, cilt.281, sa.3, ss.417-421, 2010 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 281 Sayı: 3
- Basım Tarihi: 2010
- Doi Numarası: 10.1007/s00404-009-1144-7
- Dergi Adı: Archives of Gynecology and Obstetrics
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.417-421
- Anahtar Kelimeler: Gestation, Level, Plasma, VEGF, Vitreous
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Hayır
Özet
Purpose: To evaluate the vitreous VEGF level alterations and its correlation with its plasma level if any, in gestation. Methods: The blood and vitreous sampling procedures were performed before, during. (20-23 days of gestation), and after gestation. (2 months after birth) from seven White New Zealand rabbits. Blood samples were centrifuged then supernatants and vitreous samples were stored at -80°C until assay. Measurements of serum and vitreous VEGF165 were done by ELISA. Results: The median plasma and vitreous VEGF165 concentrations were 36.61 pg/ml. (range 19.17-40.30), 14.92 pg/ml. (range 8.95-15.20); 58.30 pg/ml. (range 32.60-11.53), 20.51 pg/ml. (range 11.94-21.26); and 35.30 pg/ml. (range 27.30-39.60), 13.05 pg/ml. (range 9.33-16.04) before, during and after gestation, respectively. Both the plasma and the vitreous VEGF165 concentration during gestational period were significantly higher than pre-gestational period. (P = 0.028, P = 0.018) and post-gestational period. (P = 0.043, P = 0.028). The intravitreal VEGF 165 concentrations appeared to correlate with plasma VEGF 165 levels. (r = 0.940, P = 0.002) only in the gestational period. Conclusion: Vitreous VEGF levels increase in positive correlation with plasma VEGF during pregnancy. Further prospective studies are needed to support this finding.