Dynamic thiol disulphide homeostasis in patients diagnosed with acute pulmonary thromboembolism in emergency department Acil serviste akut pulmoner tromboemboli tanisi konulan hastalarda dinamik tiyol disülfit dengesi
Ankara Medical Journal, vol.21, no.1, pp.92-98, 2021 (Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 21 Issue: 1
- Publication Date: 2021
- Doi Number: 10.5505/amj.2021.14890
- Journal Name: Ankara Medical Journal
- Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
- Page Numbers: pp.92-98
- Keywords: Disulfides, Emergency medicine, Pulmonary embolism, Sulfhydryl compounds
- Open Archive Collection: AVESIS Open Access Collection
- Ankara Yıldırım Beyazıt University Affiliated: Yes
Abstract
Objectives: This study aims to investigate the dynamic thiol-disulfide balance in the early period of patients diagnosed with acute pulmonary thromboembolism in the emergency department. Materials and Methods: Serum thiol-disulfide levels in venous blood samples drawn from 58 patients diagnosed with acute pulmonary embolism in the emergency department were analyzed using the newly developed Erel-Neşelioğlu method, and the results were compared with the measurements of the healthy control group. In the emergency department, the pre-diagnosis of pulmonary embolism was considered with clinical and laboratory findings and confirmed with contrast-enhanced thorax computed tomography angiogram. Results: Mean native thiol and total thiol levels were significantly lower in pulmonary embolism patients compared to the control group (308.53 ± 78; 414.13 ± 50.86; p <0.002; 346.03 ± 81.13; 453.05 ± 52.46 μmol/l, p <0.003 respectively). Disulphide/native thiol and disulphide/total thiol ratios were found to be significantly higher in pulmonary embolism patients compared to the control group (p <0.001). Conclusion: Thiol-disulfide balance is altered oxidatively in patients with pulmonary embolism. This may play a role in the pathogenesis of the disease.