Role of flow cytometry in multiple myeloma and the prognostic significance of CD87 (uPAR) expression Multipl miyelomda akım sitometrinin rolü ve CD87 (uPAR) ekspresyonunun prognostik önemi
Turkish Journal of Hematology, vol.27, no.3, pp.182-189, 2010 (Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 27 Issue: 3
- Publication Date: 2010
- Doi Number: 10.5152/tjh.2010.26
- Journal Name: Turkish Journal of Hematology
- Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
- Page Numbers: pp.182-189
- Keywords: CD87 (uPAR), Flow cytometry, Multiple myeloma, uPA
- Open Archive Collection: AVESIS Open Access Collection
- Ankara Yıldırım Beyazıt University Affiliated: No
Abstract
Objective: The plasminogen activator system consists of the serine protease urokinase plasminogen activator. (uPA), two endogenous inhibitors of PAI-1 (plasminogen activator inhibitor-1) as well as the PAI-2 and uPA. receptor (uPAR or CD87). The aim of this study was to determine the significance of flow cytometry and CD87, CD45 and CD56 expressions in the diagnosis, follow-up and prognosis of multiple myeloma (MM). Materials and Methods: Twenty-nine MM patients were included in the study. Bone marrow samples. were used for flow cytometry. A panel of CD87, CD45, CD56, CD10, CD19, CD20, CD38, and CD138 was tested by flow cytometry. Results: CD87 was negative in 8 (27.5%) cases, dim positive in 9 (31.1%) and bright positive in 12 (41.4%). CD87 expression was significantly higher in CD45 (-) cases. Conclusion: Flow cytometry has a significant role in the diagnosis and prognosis of MM. Further clinical studies including large numbers of patients are needed to determine the prognostic role of CD87 in MM.