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Archives of Gynecology and Obstetrics, vol.305, no.1, pp.109-116, 2022 (SCI-Expanded)
© 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.Purpose: To investigate whether there is a relationship between the VEGF polymorphisms and idiopathic heavy menstrual bleeding (HMB-E)Query. Methods: Sixty-five patients diagnosed with HMB-E according to the FIGO classification system and 65 female healthy volunteers were included in the study. The polymorphic regions rs699947 (− 2578C > A), rs1570360 (− 1154G > A), rs2010963 (+ 405G > C), rs3025039 (+ 936C > T), rs25648 (c534C > T) in the VEGF were detected using Next Generation DNA Sequencing method. Results: The − 2578C > A polymorphism CC genotype, CA + AA genotypes, and C allele, as well as the − 1154G > A polymorphism AA genotype, and A allele were associated with increased risk of HMB-E (p < 0.05 for all). However, no statistically significant difference was found between the patient group and the control group in terms of genotype and allele distributions in the 405G > C, + 936C > T, c534C > T polymorphic regions (p > 0.05 for all). While the − 2578/ − 1154/ + 405/c534 AGGC haplotype decreased the risk of HMB-E, the CAGC haplotype was found to increase the risk of HMB-E. Conclusion: VEGF − 2578C > A and − 1154G > A polymorphisms were significantly associated with the risk of HMB-E in the Turkish population.