Children with lymphoma presenting with hemophagocytic lymphohistiocytosis

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Aksu T., Bayhan T., Gülhan B., Çakmakcı S., Oğuz A. S., Yaralı N., ...More

The Turkish journal of pediatrics, vol.62, no.2, pp.284-288, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 62 Issue: 2
  • Publication Date: 2020
  • Doi Number: 10.24953/turkjped.2020.02.016
  • Journal Name: The Turkish journal of pediatrics
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.284-288
  • Keywords: anaplastic large cell lymphoma, hemophagocytic lymphohistiocytosis, Hodgkin lymphoma
  • Ankara Yıldırım Beyazıt University Affiliated: Yes

Abstract

BACKGROUND: < 7b > Hemophagocytic lymphohistiocytosis (HLH) may precede malignancy, in particular lymphomas and leukemias. However, the causative factors, appropriate treatment and the prognosis of this association is not established. CASE: Herein, we present two patients, one with nodular sclerosing Hodgkin lymphoma (HL) and concomitant Epstein-Barr virus (EBV) infection, and the other with anaplastic large cell lymphoma (ALCL), presented as malignancy associated HLH. CONCLUSION: In our patients, malignancy directed therapy was sufficient to treat HLH symptoms both at presentation and at recurrence in the second patient.