MULTIFACETED PHYSIOLOGICAL MECHANISMS OF THERAPEUTIC Lucilia sericata LARVAE IN WOUND HEALING
18TH INTERNATIONAL İSTANBUL SCIENTIFIC RESEARCH CONGRESS, İstanbul, Türkiye, 28 - 30 Aralık 2025, ss.353-354, (Özet Bildiri)
- Yayın Türü: Bildiri / Özet Bildiri
- Doi Numarası: 10.30546/19023.978-9952-610-16-1.2025.5078.
- Basıldığı Şehir: İstanbul
- Basıldığı Ülke: Türkiye
- Sayfa Sayıları: ss.353-354
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
Larval Debridement Therapy (LDT) using Lucilia sericata (green bottle fly) larvae has proven to be an effective biological treatment, particularly for antibiotic-resistant chronic wounds. The clinical success of this method is underpinned by complex, synergistic, and coordinated physiological mechanisms that extend far beyond mere mechanical cleansing. One of the most critical initial stages of the treatment is highly selective and efficient debridement. By secreting proteolytic enzymes, the larvae digest only necrotic tissue without harming viable structures, establishing one of the fastest and most reliable methods for creating a clean wound bed conducive to healing. Crucially, this debridement is coupled with a potent and broad-spectrum antimicrobial effect. The bacteriostatic and bactericidal compounds within larval secretions exhibit efficacy against multidrug-resistant pathogens such as MRSA, providing a level of effectiveness often difficult to achieve with antibiotics alone, thereby decisively eliminating the barrier of infection. However, the definitive factor that distinguishes LDT from a simple cleansing technique is the active regenerative process initiated by larval excretions/secretions in the wound environment. These mechanisms, which directly trigger the ultimate healing outcome, aim to minimize wound closure time by stimulating fibroblast activation, promoting angiogenesis, and accelerating the formation of granulation tissue. Concurrently, the optimisation of the wound microenvironment through pH and immune modulation creates ideal biochemical conditions for tissue repair.
In conclusion, the superior therapeutic value of LDT stems not from its role as a mere debridement tool, but from its integrated capacity to control infection, perform selective tissue removal, and—most importantly—potently activate and direct the body's innate healing capacity through direct stimulation of tissue regeneration. This comprehensive, multifaceted physiological interplay positions LDT as a definitive and effective solution for wounds recalcitrant to conventional therapies.
Keywords: Larval Debridement Therapy (LDT), Lucilia sericata, Wound Healing, Biofilm / Chronic
Wound