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Journal of Gastrointestinal Surgery, vol.13, no.4, pp.798-803, 2009 (SCI-Expanded)
Background: Enoxaparin is an important molecule which had been using in prophylaxis and treatment of deep venous thrombosis. Also, it is showed that it prevents postsurgical peritoneal adhesions in rats. It is aimed to evaluate its effects on gastrointestinal wound healing. Methods: Thirty Wistar albino rats were divided into three groups as control, subcutan, and intraperitoneal enoxaparin groups. Left colon anastomoses were performed. On postoperative seventh day, anastomotic healing was evaluated by measuring anastomotic bursting pressure, tissue hydroxyproline levels, and histopathological examination. Results: The anastomotic bursting pressure was highest in subcutan enoxaparin group (p∈<∈0.001), intraperitoneal enoxaparin group (p∈<∈0.01) came the second, and the control group has the worst value. The hydroxyproline results were found nearly similar to the bursting pressure values (subcutan (p∈<∈0.001) ∈>∈intraperitoneal (p∈<∈0.05)∈>∈control). Neovascularization in subcutan group (p∈<∈0.001) has a statistically significant difference to other groups. Conclusion: Enoxaparin did not interfere with colonic anastomotic resistance but improved the intestinal wound healing. © 2008 The Society for Surgery of the Alimentary Tract.