The Relationship Between Vitamin-D Deficiency and Protein Oxidation Among Obese Children
Fetal and Pediatric Pathology, vol.42, no.4, pp.599-613, 2023 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 42 Issue: 4
- Publication Date: 2023
- Doi Number: 10.1080/15513815.2023.2183026
- Journal Name: Fetal and Pediatric Pathology
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, EMBASE, MEDLINE
- Page Numbers: pp.599-613
- Keywords: thiol-disulfide homeostasis, vitamin D, obese, pre-obese, children
- Ankara Yıldırım Beyazıt University Affiliated: Yes
Abstract
Aim: The aim of the study is to examine the relationship between obesity, Vitamin-D deficiency, and protein oxidation. Methods: Thiol-disulfide homeostasis, Vitamin-D, ischemia modified albumin, insulin, and lipid levels were compared among obese, pre-obese and normal-weight healthy children. Results: A total of 136 children (69 boys and 67 girls) were included in the study. The vitamin-D levels of obese children were lower than those of pre-obese and normal weight (p < 0.05). In the normal weight group, total thiol and native thiol were lower in the pubertal period than in adolescence; were higher in those with sufficient Vitamin-D level than those with insufficient and deficient Vitamin-D (p < 0.05). Vitamin-D level was lower in pre-obese girls than boys (p < 0.05). Those with high triglycerides had high disulfide/total thiol, disulfide, and disulfide/native thiol and low native thiol/total thiol (p < 0.05). Conclusion: Thiol-disulfide homeostasis is negatively affected by low vitamin D levels, pubertal period and high triglyceride levels.