EVALUATION OF LARGE UNSTAINED CELLS (LUC) AND NITRIC OXIDE IN DIABETES MELLITUS
Ankara Medical Journal, cilt.22, sa.4, ss.533-541, 2022 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 22 Sayı: 4
- Basım Tarihi: 2022
- Doi Numarası: 10.5505/amj.2022.65707
- Dergi Adı: Ankara Medical Journal
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.533-541
- Anahtar Kelimeler: Diabetes Mellitus, inflammation, LUC, NO
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
Objectives: The large unstained cells (LUC) is a differential count parameter measured by routine hematology analyzers and reflects activated lymphocytes and peroxidase-negative cells in leukocytes. Nitric oxide (NO) is produced in all tissues in enzymatic and non-enzymatic ways. This study aimed to determine the levels of LUC and NO products (nitrite and nitrate) and to evaluate the LUC/NO ratio in patients with Diabetes Mellitus (DM). Materials and Methods: The study included 103 DM patients and 84 healthy controls. HbA1c, LUC/%LUC and total NO levels were measured. All the statistical calculations were performed using the Statistical Package for Social Sciences (SPSS) software program. Results: Nitric oxide levels of the patients were statistically significantly lower compared with the control group (p=0.004). LUC levels, LUC% values, LUC/NO, and LUC%/NO ratios were significantly higher in the DM group (p=0.002, p=0.009, p= <0.001, and p= <0.001, respectively). Statistically significant correlations were observed between HbA1c and nitrite, nitrate, NO, LUC/NO ratio, and LUC % /NO ratio. Conclusion: In this study, we determined the LUC/NO percent ratio and LUC%/NO percent ratio for the first time, according to our knowledge. We predict that these two parameters may be useful markers in the diagnosis and the follow-up of the disease and may provide target pathways for further studies that may contribute to the etiopathogenesis of the disease.