Effects of diosmine-hesperidine on experimental colonic anastomosis
Bratislava Medical Journal, cilt.113, sa.12, ss.692-697, 2012 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 113 Sayı: 12
- Basım Tarihi: 2012
- Doi Numarası: 10.4149/bll_2012_157
- Dergi Adı: Bratislava Medical Journal
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.692-697
- Anahtar Kelimeler: Colonic anastomosis, Diosmine-hesperidine
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Hayır
Özet
Aim: Our goal was to determine the effects of a diosmine-hesperidine combination on wound healing in a rat model ofcolonic anastomosis. Materials and methods: In this study, 20 Wistar Albino female rats were randomized into four experimental groups containing fi ve rats in each group. A segment of 1 cm of colon was excised 4 cm proximally to the peritoneal refl ection in all rats without carrying out any mechanical or antibacterial bowel preparation. Colonic anastomosis was performed with interrupted, inverting sutures of 6/0 polypropylene. Beginning from the fi rst postoperative day, therats in Groups II and IV received 100 mg/kg per day of diosmine-hesperidine via orogastic route by 4F fi ne feeding catheter. Results: A signifi cant difference was detected between groups in terms of their hydroxyproline levels (p<0.05); the hydroxyproline level of Group I was signifi cantly lower than that of the other groups while no signifi cant difference was noted between Groups II and III. Conclusion: The administration of diosmine-hesperidine increased the amount of collagen and bursting pressures at the anastomotic site and thus had favorable infl uences on the healing of colonic anastomosis.