Comparing S-100 beta protein levels and neurocognitive functions between patients undergoing on-pump and off-pump coronary artery bypass grafting

Bayram H., Hidiroglu M., Cetin L., Kucuker A., İRİZ E., UĞUZ E., ...Daha Fazla

Journal of Surgical Research, cilt.182, sa.2, ss.198-202, 2013 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 182 Sayı: 2
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.jss.2012.10.047
  • Dergi Adı: Journal of Surgical Research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.198-202
  • Anahtar Kelimeler: Cardiopulmonary bypass, Neurobehavioral manifestations, Off-pump coronary artery bypass, S-100 beta protein
  • Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet

Özet

Background: In the present study, we aimed to investigate the effects of off-pump coronary artery bypass grafting and on-pump cardiopulmonary bypass on the serum S-100 beta (S-100B) protein levels and neurocognitive functions of the patients. Materials and methods: Sixty-four patients undergoing coronary artery bypass grafting (CABG) were enrolled in the study and were divided into two groups: off-pump (group I, n = 24) and on-pump CABG (group II, n = 40) group. Serum S-100B levels were measured before and 0, 6, and 24 h after the operation. Neurocognitive function tests were done preoperatively and were repeated in the postoperative period as well. Results: Serum S-100B levels were similar between the two groups preoperatively. However, median S-100B levels at 0, 6, and 24 h after the surgery were found to be significantly lower in the off-pump CABG group than in the on-pump group. The preoperative neurocognitive functions of the patients were similar between the two groups, whereas neurocognitive function was found to be significantly impaired postoperatively in the on-pump group in comparison with the off-pump CABG group. Conclusion: We concluded that off-pump CABG is associated with decreased serum S100 protein levels and less impairment on neurocognitive functions compared with the on-pump group. © 2013 Elsevier Inc. All rights reserved.