The Effect of Bolus Vitamin D Supplementation

Bozkurt S., Alkan B., URAL F. G., Aksekili H., FİDAN F., SEZER N., ...More

Ankara Medical Journal, vol.19, no.2, pp.288-299, 2019 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 2
  • Publication Date: 2019
  • Doi Number: 10.17098/amj.582000
  • Journal Name: Ankara Medical Journal
  • Page Numbers: pp.288-299
  • Ankara Yıldırım Beyazıt University Affiliated: Yes


Objectives: Vitamin D plays an important role in musculoskeletal and nervous systemhealth. Although, the prevalence of vitamin D deficiency is fairly high and it may lead to boneabnormalities and muscle weakness, it is a preventable condition. The aim of this prospective studywas to assess the effects of vitamin D supplementation on balance, mobility, grip strength, fatigue,depression and quality of life.Materials and Methods: Between October 1, 2015 and December 31, 2015, a total of 92 patients withvitamin D insufficiency/deficiency were included in the study. Demographic characteristics of age,gender, height, weight, serum 25‐hydroxyvitamin [25‐(OH)D], parathyroid hormone, alkalinephosphatase (ALP), calcium, and phosphorus levels were recorded. The primary outcome wasassessed the [25‐(OH) D] levels at 1 month and 3 month post‐treatment. The secondary outcomeswere the efficacy of vitamin D administration on fatigue, mobility, balance, depression, quality of life(QoL), muscle strength using The Multidimensional Assessment of Fatigue Scale (MAF), Timed Upand Go Test (TUG), Single leg stance test (SLS), Beck Depression Inventory (BDI), The NottinghamHealth Profile(NHP), hand dynamometer, respectively at all visits. Results: After the 1 month, the vitamin D supplementation had significantly improved musclestrength, balance ability, mobility, QoL, depression, and fatigue symptoms. The levels of [25‐(OH) D]significant decreased after 3 months.Conclusion: Supplemental vitamin D consistently demonstrated beneficial effects on musclestrength, mobility, balance control, depression, fatigue and QoL. The 300,000 bolus of vitamin D waswell‐tolerated and safe in adult population. We would recommend evaluating vitamin D status oncein three months