Comparison of the effects of latanoprost and bimatoprost on central corneal thickness

Sen E., Nalcacioglu P., Yazici A., Nur Aksakal F., Altinok A., Tuna T., ...Daha Fazla

Journal of Glaucoma, cilt.17, sa.5, ss.398-402, 2008 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 5
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1097/ijg.0b013e31815d784c
  • Dergi Adı: Journal of Glaucoma
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.398-402
  • Anahtar Kelimeler: Bimatoprost, Central corneal thickness, Intraocular pressure, Latanoprost
  • Ankara Yıldırım Beyazıt Üniversitesi Adresli: Hayır

Özet

PURPOSE: To compare the effects of latanoprost and bimatoprost on central corneal thickness (CCT). MATERIALS AND METHODS: A total of 188 eyes of 94 patients who were being followed in our hospital's glaucoma clinic and were receiving either latanoprost (55.3%) or bimatoprost (44.7%) monotherapy were recruited for the study. The data were collected prospectively from the patients, who were medicated with bimatoprost or latanoprost, at the initial diagnosis of glaucoma. Measurements were performed at the initial diagnosis, 6th, 12th, and 24th months. All the measurements were carried out by the same doctor between 9 AM and 11 AM, using Goldmann applanation tonometer for intraocular pressure (IOP) and ultrasound biopachymeter for CCT. RESULTS: There were no significant differences between the patient groups receiving latanoprost or bimatoprost for sex, age, baseline IOP, and CCT. The mean baseline CCT values were 559.5±35.3μm for latanoprost group and 553.4±31.7μm for bimatoprost group. CCT of both groups at 6, 12, and 24 months were significantly thinner when compared with baseline CCT. The percent reduction rates were 1.9±2.4% for latanoprost and 2.8±1.8% for bimatoprost in the 24th month. CONCLUSION: A significant reduction in CCT was observed at the 6th, 12th, and 24th months with latanoprost and bimatoprost. Serial CCT measurements in determining the IOP values may be helpful in the follow-up of prostaglandin analogs. © 2008 by Lippincott Williams & Wilkins.