Significance of MPV, RDW and PDW with the Severity and Mortality of COVID-19 and Effects of Acetylsalicylic Acid Use

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Aydınyılmaz F., Aksakal E., Pamukcu H. E., Aydemir S., Doğan R., Saraç İ., ...More

Clinical and Applied Thrombosis/Hemostasis, vol.27, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27
  • Publication Date: 2021
  • Doi Number: 10.1177/10760296211048808
  • Journal Name: Clinical and Applied Thrombosis/Hemostasis
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
  • Keywords: mean platelet volume, platelet distribution width, red cell distribution width, COVID-19
  • Ankara Yıldırım Beyazıt University Affiliated: No


We aimed to investigate association between mean platelet volume (MVP), platelet distribution width (PDW) and red cell distribution width (RDW) and mortality in patients with COVID-19 and find out in which patients the use of acetylsalicylic acid (ASA) affects the prognosis due to the effect of MPV on thromboxan A2. A total of 5142 patients were divided into those followed in the intensive care unit (ICU) and those followed in the ward. Patient medical records were examined retrospectively. ROC analysis showed that the area under curve (AUC) values were 0.714, 0.750, 0.843 for MPV, RDW and D-Dimer, the cutoff value was 10.45fl, 43.65fl, 500.2 ng/mL respectively. (all P <.001). Survival analysis showed that patients with MPV >10.45 f/l and D-Dimer >500.2 ng/mL, treatment with ASA had lower in-hospital and 180-day mortality than patients without ASA in ICU patients (HR = 0.773; 95% CI = 0.595-0.992; P =.048, HR = 0.763; 95% CI = 0.590-0.987; P =.036). Administration of low-dose ASA in addition to anti-coagulant according to MPV and D-dimer levels reduces mortality.