Anti-obesity potential of Elaeagnus angustifolia L. associated with phenolic profiles determined by LC-qTOF-MS
NATURAL PRODUCT RESEARCH, cilt.0, sa.0, ss.1-10, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 0 Sayı: 0
- Basım Tarihi: 2026
- Doi Numarası: 10.1080/14786419.2026.2669211
- Dergi Adı: NATURAL PRODUCT RESEARCH
- Derginin Tarandığı İndeksler: Scopus, Science Citation Index Expanded (SCI-EXPANDED), Chemical Abstracts Core, CINAHL, EMBASE, MEDLINE
- Sayfa Sayıları: ss.1-10
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
Abstract
Obesity significantly impairs quality of life through physical and psychological effects, requiring effective therapeutic strategies. This study is the first to investigate the anti-obesity potential of different organs of Elaeagnus angustifolia on 3T3-L1 adipocyte differentiation and function. Cytotoxicity assays showed IC50 values ranging approximately from ∼0.6 to 2.5 mg/mL, indicating acceptable safety values. Both ethanol and aqueous extracts reduced lipid accumulation in mature adipocytes, with inhibition ranging from ∼10% to over 55%, the strongest effect observed in the aqueous extracts from young leaves. Genotoxicity testing revealed only minor, non-significant increases in DNA fragmentation (<10%). LC-qTOF-MS-based metabolite fingerprinting identified phenolics, terpenes, alkaloids, and carboxylic acids as major constituents. Notably, anti-obesity activity was strongly correlated (r ≈ 0.9–1.0) with compounds such as epicatechin, genistein, isoorientin, corosolic acid, and loganic acid. Overall, these findings highlight young leaves as the most promising source for dietary supplementation aimed at obesity management.