Obesity-associated redox shift in thiol–disulfide homeostasis: A community-based study of metabolic syndrome

Katar M., Onder Y., Citil R., NEŞELİOĞLU S., EREL Ö.

International Journal of Medical Biochemistry, cilt.9, sa.3, ss.133-140, 2026 (ESCI, Scopus, TRDizin)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Sayı: 3
  • Basım Tarihi: 2026
  • Doi Numarası: 10.14744/ijmb.2026.32704
  • Dergi Adı: International Journal of Medical Biochemistry
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.133-140
  • Anahtar Kelimeler: Biomarkers, clinical phenotype, metabolic syndrome, oxidative stress, redox balance, thiol–disulfide homeostasis
  • Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet

Özet

Objectives: Oxidative stress is a central feature of metabolic syndrome (MetS); however, the relationship between thiol–disulfide homeostasis and the clinical manifestations of MetS remains unclear. This study aimed to evaluate the association between thiol–disulfide balance and MetS, focusing on clinical and anthropometric parameters. Methods: In this cross-sectional study, 1012 adults were categorized according to MetS status. Serum native thiol, total thiol, and disulfide levels were measured, and ratio-based indices were calculated. Anthropometric measurements and blood pressure were recorded. Group comparisons, correlation analyses, and multivariate logistic regression analyses were performed. Results: Individual thiol parameters did not differ significantly between the groups. However, the disulfide-to-native thiol ratio was significantly higher in individuals with MetS and remained independently associated with MetS after ad-justment for age, sex, and body mass index. Significant but modest correlations were observed between thiol–disulfide indices and obesity-related anthropometric measures. Conclusion: Ratio-based thiol–disulfide indices may better reflect systemic oxidative stress in MetS than individual pa-rameters. These findings support the potential utility of integrated redox markers as indicators of metabolic dysfunction.