Robust diagnosis of Ewing sarcoma by immunohistochemical detection of super-enhancer-driven EWSR1-ETS targets

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Baldauf M. C., Orth M. F., Dallmayer M., Marchetto A., Gerke J. S., Rubio R. A., ...More

ONCOTARGET, vol.9, no.2, pp.1587-1601, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 2
  • Publication Date: 2018
  • Doi Number: 10.18632/oncotarget.20098
  • Journal Name: ONCOTARGET
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1587-1601
  • Ankara Yıldırım Beyazıt University Affiliated: No

Abstract

Ewing sarcoma is an undifferentiated small-round-cell sarcoma. Although molecular detection of pathognomonic EWSR1-ETS fusions such as EWSR1-FLI1 enables definitive diagnosis, substantial confusion can arise if molecular diagnostics are unavailable. Diagnosis based on the conventional immunohistochemical marker CD99 is unreliable due to its abundant expression in morphological mimics.