The association of serum lipocalin-2 levels with metabolic and clinical parameters in obese children: a pilot study.


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Akelma A., Abaci A., Ozdemir O., Celik A., Avci Z., Razi C., ...More

Journal of pediatric endocrinology & metabolism : JPEM, vol.25, pp.525-8, 2012 (Journal Indexed in SCI Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 25
  • Publication Date: 2012
  • Doi Number: 10.1515/jpem-2011-0477
  • Title of Journal : Journal of pediatric endocrinology & metabolism : JPEM
  • Page Numbers: pp.525-8

Abstract

Objective: We aimed to evaluate the association between

serum lipocalin-2 level and clinical and metabolic parameters

in obese children.

Methods: The study included obese children with a

body mass index (BMI) > 95th percentile who presented

to Kecioren Teaching and Research Hospital with the

complaint of weight gain and healthy children with a

BMI < 85th percentile. The height and weight of the

patients were measured for compartment of anthropometric

data. Fasting blood glucose, insulin, lipid profi le,

and serum lipocalin-2 level were measured to evaluate the

laboratory parameters.

Results: The study included 33 obese and 34 healthy nonobese

children. Comparison of data on the obese subjects with

those of the healthy subjects shows differences in BMI, BMISDS,

triglyceride, insulin, and homeostasis model assessment

index-insulin resistance levels between the two groups were

statistically signifi cant (p < 0.05), whereas serum lipocalin-2

was not statistically signifi cant (p > 0.05). There was no statistically

signifi cant difference in serum lipocalin-2 levels when

obese and control groups were reclassifi ed as prepubertal and

pubertal (p > 0.05).

Conclusions: In this study, we did not fi nd any relationships

among serum lipocalin-2 level, anthropometric parameters, or

metabolic parameters. According to the results of this study,

we do not suggest routine investigation of serum lipocalin-2

level in obese subjects for risk stratifi cation of the obesityrelated

complications.