The Effect of Acute Stroke Treatment on S100B, IMA, and Thiol-Disulfide Balance
Neurology India, cilt.72, sa.6, ss.1231-1236, 2024 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 72 Sayı: 6
- Basım Tarihi: 2024
- Doi Numarası: 10.4103/ni.ni_511_22
- Dergi Adı: Neurology India
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, Veterinary Science Database
- Sayfa Sayıları: ss.1231-1236
- Anahtar Kelimeler: EVT, IMA, lschemic stroke, native thiol, S100B, total thiol, tPA
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
Background: A variety of processes, ranging from blood-brain barrier disruption to circulating biomarkers, contributes to reperfusion injury in acute stroke treatment. Objective: We aimed to investigate the effects of thrombolytic therapy and endovascular thrombectomy therapy on serum S100 calcium-binding protein B, ischemia-modified albumin and thiol-disulfide balance in patients who arrived within the first 6 h of acute ischemic stroke. Material and Methods: The study considered 66 patients with the diagnosis of acute ischemic stroke who underwent thrombolytic therapy or EVT in the first 6 h, as well as 32 healthy volunteers. Venous blood samples were collected before tPA and EVT and 24 h after treatment. S100B, native thiol, disulfide, total thiol, and Ischemia-modified albumin (IMA) levels were measured. Results: The S100B, total thiol, and native thiol values of the patients in the tPA group before and after the treatment showed statistical significance (P < 0.001). S100B, total thiol, and native thiol values were shown to be lower. The disulfide and IMA values of the patients in the tPA group did not differ significantly (respectively, P = 0.302, P = 0.054). However, disulfide and IMA levels were found to increase after treatment compared to pretreatment. The patients in the EVT group showed a significant difference in terms of S100B values (P < 0.001) and IMA values (P = 0.024). Conclusions: Determining how to protect the brain from free radical damage is important. More research should be carried out on treatments that prevent free radical damage in ischemia-reperfusion injury, as well as treatments for acute ischemic stroke.