Evaluation of Subclinical Inflammation with Neutrophil Lymphocyte Ratio In Heavy Metal Exposure

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BAL C. , Karakulak U., Gunduzoz M., Ercan M., Tutkun E., Yilmaz O. H.

JOURNAL OF CLINICAL AND ANALYTICAL MEDICINE, vol.7, no.5, pp.643-647, 2016 (Journal Indexed in ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 5
  • Publication Date: 2016
  • Doi Number: 10.4328/jcam.4393
  • Page Numbers: pp.643-647


Aim: Neutrophil lymphocyte ratio (NLR) is being used frequently as a marker of subclinical inflammation. The objective of this study is to investigate the association between NLR levels and heavy metal levels in workers with lead exposure. Material and Method: Demographic and laboratory data of 1820 individuals with lead exposure were evaluated retrospectively. C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and complete blood count (CBC) were evaluated as inflammatory markers. Participants were categorized into 3 groups according to blood lead levels as <10 mu g/dL (Group 1), 10-30 mu g/dL (Group 2), and > 30 mu g/dL(Group 3). The association between NLR and lead was evaluated by inter-group and correlation analysis. Results: Median NLR values of Group 1, Group 2 and Group 3 were 1.45 (1.57), 1.90 (6.44), and 1.96 (6.36) respectively (p<0.001). NLR correlated positively with blood lead levels (r=0.412; p<0.001). A positive correlation was also detected with CRP, ESR, white blood cell (WBC), neutrophil, and mean platelet volume (MPV) levels (r=0.140; p<0.001, r=0.075; p=0.002, r=0.237; p<0.001, r=0.585; p<0.001, r=0.060; p<0.012, respectively). There was a negative correlation with lymphocyte (r=-0.536; p<0.001). Discussion: To our best knowledge, this study is the first one which shows a strong and dose-dependent association between NLR and lead levels.