Salivary opiorphin in dental pain: A potential biomarker for dental disease

Ozdogan M. S. , Gungormus M. , Yusufoglu S. , Ertem S. Y. , Sonmez C., Orhan M.

Archives of Oral Biology, vol.99, pp.15-21, 2019 (Journal Indexed in SCI Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 99
  • Publication Date: 2019
  • Doi Number: 10.1016/j.archoralbio.2018.12.006
  • Title of Journal : Archives of Oral Biology
  • Page Numbers: pp.15-21


Objectives: Opiorphin is a recently discovered peptide shown to inhibit the enkephalin-degrading enzymes and prolong the effects of enkephalins. Although opiorphin is found in high concentrations in saliva, the relationship between salivary opiorphin and orofacial pains is not yet fully understood. We aimed to determine salivary opiorphin concentrations in dental pain related to symptomatic irreversible pulpitis (SIP), and symptomatic apical periodontitis (SAP).