Liver enzymes, mean platelet volume, and red cell distribution width in gestational diabetes

Erdoǧan S., Özdemir Ö., Doǧan H. O. , Sezer S., Atalay C. R. , Yilmaz F. M. , ...More

Turkish Journal of Medical Sciences, vol.44, no.1, pp.121-125, 2014 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 1
  • Publication Date: 2014
  • Doi Number: 10.3906/sag-1301-41
  • Journal Name: Turkish Journal of Medical Sciences
  • Journal Indexes: Science Citation Index Expanded, Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.121-125
  • Keywords: Alanine transaminase, Gestational diabetes, Platelet count, Platelet distribution width, γ-glutamyl transferase


Aim: To investigate the value of measuring liver enzymes, red cell distribution width (RDW), and mean platelet volume (MPV) in predicting the development of gestational diabetes mellitus (GDM). Materials and methods: The medical records of all pregnant women followed by the obstetrics clinic between January 2010 and November 2012 were systematically evaluated, and patients with a diagnosis of GDM were identified. A total of 68 patients with GDM and 61 healthy controls were included in the study. Results of relevant laboratory parameters were recorded. Results: Out of all the parameters evaluated, mean values for platelet distribution width (PDW) and mean activities of alanine transaminase (ALT) and γ-glutamyl transferase (GGT) were significantly higher in the GDM group compared to healthy controls (P = 0.003, P = 0.015, and P = 0.021, respectively), whereas mean plateletcrit (PCT) levels were significantly lower in the GDM group (P = 0.002). No significant difference was observed between groups in terms of MPV, RDW, platelet count, and aspartate transaminase levels. Conclusion: Our study results suggest that ALT, GGT, PCT, and PDW may be useful as predictors of impending GDM. © TÜBİTAK.