Pozzolanic activity of clinoptilolite, the most common natural zeolite mineral, was studied in comparison to silica fume, fly ash and a non-zeolitic natural pozzolan. Chemical, mineralogical and physical characterizations of the materials were considered in comparative evaluations. Pozzolanic activity of the natural zeolite was evaluated with various test methods including electrical conductivity of lime-pozzolan suspensions; and free lime content, compressive strength and pore size distribution of hardened lime-pozzolan pastes. The results showed that the clinoptilolite possessed a high lime-pozzolan reactivity that was comparable to silica fume and was higher than fly ash and a non-zeolitic natural pozzolan. The high reactivity of the clinoptilolite is attributable to its specific surface area and reactive SiO2 content. Relatively poor strength contribution of clinoptilolite in spite of high pozzolanic activity can be attributable to larger pore size distribution of the hardened zeolite-lime product compared to the lime-fly ash system. © 2009 Elsevier Ltd. All rights reserved.