Choroidal vascularity index in adult patients with familial meditteranean fever

Timur İ. E. E., Atalar E., Maraş Y., Dağ Şeker E., YÜZBAŞIOĞLU S., UĞURLU N.

Photodiagnosis and Photodynamic Therapy, cilt.42, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1016/j.pdpdt.2023.103350
  • Dergi Adı: Photodiagnosis and Photodynamic Therapy
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Anahtar Kelimeler: Binarized image, Choroidal thickness, Choroidal vascularity index, Chronic inflammation, Familial mediterranean fever, OCT
  • Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet

Özet

Purpose: This study aimed to evaluate choroidal vascular status by the choroidal vascularity index (CVI) in adult patients with familial Mediterranean fever (FMF) in remission period. Materials-methods: 86 patients diagnosed with FMF and 54 healthy controls were recruited in this study. Retinal, ganglion cell complex and peripapillary retinal nerve fibre layer thicknesses were obtained using Spectralis domain-optical coherence (SD-OCT) tomography. Choroid images were obtained with the enhanced depth imaging mode of SD-OCT, and binarization was applied to the images using ImageJ software. CVI was described as the proportion of the luminal area to the total choroidal area. Blood-derived inflammation markers were calculated by the complete blood count. Results: The subfoveal choroidal thickness and nasal and temporal directions from fovea centralis at 500 μm, 1000 μm and 1500 μm were reduced in patients with FMF in comparison to healthy controls (p<0.001, each comparison). CVI was significantly decreased in patients with FMF compared to controls (62.28±2.2 and 64.79±4.3, p<0.001). Conclusion: We concluded that the choroidal vasculature structure may be affected prior to retinal changes in patients with FMF.