Serum selenium, zinc, copper and iron concentrations and some related antioxidant enzymes in patients with cutaneous leishmaniasis
Marmara Medical Journal, cilt.11, sa.2, ss.77-82, 1998 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 11 Sayı: 2
- Basım Tarihi: 1998
- Dergi Adı: Marmara Medical Journal
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.77-82
- Anahtar Kelimeler: Catalase, Copper, Cu-Zn superoxide dismutase, Cutaneous leishmaniasis, Glutathione peroxidasel, Iron, Selenium, Zinc
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
Objective: This study has been carried out to measure the alterations of some trace element concentrations, their related antioxidant enzyme activities, and carrier proteins in patients with cutaneous leishmaniasis (CL). Methods: Serum selenium, zinc concentrations were determined Atomic Absorption Spectrometer. Erythrocyte Cu-Zn superoxide dismutase (Cu-Zn SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) activities and ceruloplasmin (Cp) levels were measured with enzymatic colorimetric methods and transferrin (Tf) levels were measured with turbidimetric method. Results: Erythrocyte Cu-Zn SOD activities, serum copper concentrations and Cp levels were found to be significantly higher in patients group, than those of controls. However, GSH-Px and CAT activities, and selenium, zinc, iron and Tf levels were lower in patients according to the control subjects. There were positive important correlations between Cu-Zn SOD and Cp, Cu-Zn SOD and copper, Cp and copper, GSH-Px and selenium, and iron and CAT in patients group. Conclusion: Our results showed that serum essential trace elements selenium, zinc, copper and iron concentrations and their related enzymes Cu-Zn SOD, GSH-Px and CAT activities change in CL patients. The changes may be a part of defense strategies of organism and are induced by the hormone-like substances.