Linezolid and dexamethasone experience in a serious case of listeria rhombencephalitis

Yılmaz P. Ö., Mutlu N. M., SERTÇELİK A., Baştuğ A., Doğu C., Kışlak S.

Journal of Infection and Public Health, vol.9, no.5, pp.670-674, 2016 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 5
  • Publication Date: 2016
  • Doi Number: 10.1016/j.jiph.2015.12.018
  • Journal Name: Journal of Infection and Public Health
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.670-674
  • Keywords: Dexamethasone, Linezolid, Listeria rhombencephalitis
  • Ankara Yıldırım Beyazıt University Affiliated: No


Listeria rhombencephalitis is a rare cause of brain stem encephalitis. We report a case with a history of immunosupressive therapy due to Takayasu's arteritis that was treated with corticosteroids and linezolid for Listeria rhombencephalitis. A 63-year-old woman was admitted to the hospital with fever, headache, nausea, and vomiting. The patient's body temperature was 38 °C, and she had a stiff neck. Listeria monocytogenes was isolated from the cerebrospinal fluid (CSF), and penicillin G and gentamicin treatment was initiated. Linezolid and dexamethasone were added. Due to hematuria and thrombocytopenia, the linezolid was discontinued. In immunocompromised patients with CNS infections, Listeria rhombencephalitis should be suspected. Linezolid can be used in combination with dexamethasone.