Aim: Prone CPR has gained popularity recently during the COVID-19 pandemic. Prone CPR can be used to manage cardiopulmonary arrest in patients who are being treated in a prone position with an advanced airway in place or in patients who are being operated on in the prone position. It is important that physicians who work in the emergency department and intensive care units, where patients are treated in a prone position, have knowledge about prone CPR. In this study, our goal was to determine emergency department and intensive care physicians’ level of knowledge about prone CPR as well as whether they have received training on prone CPR and whether they have applied prone CPR in their practice. Material and Methods: This study surveyed physicians working in a hospital in the city center with approximately 650,000 emergency department presentations aannually and 700 intensive care beds; the survey was conducted between December 2020 and March 2021. The participants were asked a total of 24 question, 18 of which elicited demographic information and educational status and six of which measured theoretical knowledge about prone CPR. The analysis of the data was performed using IBM SPSS 16.0 for Windows, and the significance value was accepted as p < 0.05. Results: A total of 112 physicians participated in the study, 85 of whom were residents and 27 of whom were specialists. While 101 of the participants were working in the emergency room, 11 were working in the intensive care unit. The data indicated that, although the majority of the participants followed prone patients, they had not received training on prone CPR (86.6%) and did not perform prone CPR (92%). Conclusion: Despite the increase in the number of patients followed in prone position and the use of prone CPR during the COVID-19 pandemic, physicians’ lack of knowledge and experience with prone CPR continues; therefore, prone CPR needs to be included in CPR education.