Şizofreni Hastaları ve Şizofreni Hastalarının Birinci Derece Yakınlarında Motor Becerilerin Değerlendirilmesi ve Sağlıklı Kontrol Grubu ile Karşılaştırılması


Thesis Type: Expertise In Medicine

Institution Of The Thesis: Ankara Yildirim Beyazit University, Tıp Fakültesi, Ruh Sağlığı Ve Hastalıkları Ana Bilim Dalı, Turkey

Approval Date: 2020

Thesis Language: Turkish

Student: Emine Tuğçe KAYA

Supervisor: ALİ ÇAYKÖYLÜ

Abstract:

Introduction: Neurological symptoms such as dyskinesia, parkinsonism, extrapyramidal symptoms, neurological soft signs, and fine motor impairment in schizophrenia are symptoms that are observed throughout the course of the disease and are included in the pathophysiology. The impairment in motor functions is observed not only in schizophrenia patients, but also in unaffected relatives of schizophrenia, and in populations at risk. Therefore, motor abnormalities are considered a potential endophenotype feature for schizophrenia. In this study, we aimed to compare schizophrenia patients with first degree schizophrenia relatives without psychiatric disease and healthy controls in terms of different motor domains. In the study, impairment in all areas of motor skills is expected in patients with schizophrenia compared to other control groups and deterioration is expected in the relatives of schizophrenia patients in some areas according to healthy controls. Method: Thirty-four patients with schizophrenia, 31 first-degree schizophrenia relatives (mother-father or sibling) who were not diagnosed with any psychiatric disorder, and 32 healthy individuals, matched for age, gender and education level were included in our study. Motor functions are examined under four domains in each group: Neurological Soft Signs (NSS), Abnormal Involuntary Movements Scale (dyskinesia), Parkinsonism, and fine motor skills (with the Coin Rotation Test used for complex fine motor skills). In addition, the groups were compared in terms of motor functions, frontal lobe functions and working memory. Results: In the schizophrenia group, neurological soft signs, impaired fine motor skills, dyskinesia and Parkinsonism symptoms were found to be significantly higher than the other groups. Impairment in general neurological symptoms, including complex fine motor skills, has been found in patients with schizophrenia. In the relatives of schizophrenia, symptoms such as neurological soft signs and impaired fine motor skills were found to be significantly higher than healthy controls. There was no significant difference between the two groups in terms of dyskinesia and parkinsonism. Discussion: Motor abnormalities are evident in patients with schizophrenia. Increase in neurological soft signs and impairment in complex fine motor skills in the relatives of schizophrenia can be considered as genetic risk markers at a certain level in terms of schizophrenia. In order to understand the pathophysiology of complex fine motor impairment, including some instrumental approaches, studies in the field of neurological symptoms in schizophrenia may contribute to this area. However, the same relationship could not be established for Parkinsonism and dyskinesia. Therefore, it seems unlikely that Parkinsonism and dyskinesia are genetic markers for psychosis.